Source:http://cegg.unige.ch/insecta/immunodb/expert

JAKSTATs: Signal Transduction
Summary

Sang Woon Shin, Guowu Bian, Kanwal Alvarez, and Alexander Raikhel 

Department of Entomology and the Institute for Integrative Genome Biology, University of California, Riverside California 92521, USA 

Innate immune signal transduction pathways connect the extracellular recognition and amplification signals with intracellular transcriptional activation of a large repertoire of immune molecules including AMPs. The insect innate immune system relies on two major signaling pathways, Toll and Imd pathways. In Drosophila, the Toll pathway activates antifungal defenses and mediates response to Gram-positive (+) bacteria infection, whereas the IMD pathway is activated by Gram-negative (-) bacteria infection [Brennan and Anderson, 2004]. 

The JAK-STAT pathway is the third pathway involved in immune responses and haematopoiesis in An. gambiae and Drosophila [Barillas-Mury et al. 1999; Agaisse et al. 2003; Sorrentino et al. 2004; Markus et al. 2005]. In addition, the Drosophila JAK-STAT pathway has been shown to mediate innate antiviral response [Dostert et al. 2005]. In Drosophila, UPD3, a cytokine-like molecule, is expressed by circulating hemocytes upon septic injury to activate the JAK-STAT pathway in fat body cells [Agaisse et al. 2003]. Other components of the pathway consist of a transmembrane receptor Domeless (Dome) [Brown et al. 2001], a JAK kinase Hopscotch (HOP) [Binari & Perrimon 1994] and a transcription factor STAT (STAT92E) [Hou et al. 1996]. In An. gambiae, STAT1 is generated from an intron-less gene, and is activated in fat body cells in response to bacterial challenge [Barillas-Mury et al. 1999]. An additional STAT, STAT2, was identified from the genome, which has six introns [Christophides et al. 2002]. In Ae. aegypti, 1:1 orthologs to Drosophila Dome, HOP, STAT are found in the genome.


No JAK/STAT pathway genes were annotated in Oncopeltus fasciatius OGS v1.1b


domeless 2 did not have protein sequence so I translated it using http://web.expasy.org/translate/
>domeless 2 | ACYPI004970 | JAK/STAT Pathway | | | Acyrthosiphon pisum | Brucker et al., 2012
GTAACCGTTCCGAGAGGTGATATTGTCATTGAATACGGTTCCGGCACCCCCTTGGAAATCACGTGCGTCTTAGATCCCGACAATGAAAATGTGCAACACCTGTTTCGGAATGACACCAACGATGGCGGTGAAGCTAAAACACCGAGCCAGCGGATCCTGTTCTACAAGAACGCCGAACGCGTGTCCAGACAGTACATGACGATTATCAACGCAACGGCCGCTCAATTGCGCATTTCCAATCCACCAGCAGGCCGAGATACCTATTATTGCGTGCTGTTACTTGACGACCAACTGGGTCTAAACCACAGCTATGACAACATGAGTACTGCTCAGTTGTTATCCACATCGTCAAGTGATTCGTCGACATTTCCCACCCCGCCACCGACGAGCTTGGAAACTAGTGGTCCACCCTCGCTGGTATCACAAACCTCTGAGGTCGGGGTGTGTCTCAACAGCGTTGCCGTTGGATATAAACCGGCCCCAATTACAAATTTTTCTTGTATATCTGACAATTGGGTAAGTTTGACGTGCAATTGGACCAAACCAGAGAACCCAATTAAAACATCATATAAGTTATTCTTCAGATTACCTGGTCGTGCTGGAGGCAGAACTATTATAAATTGTCCTAAGGATTCAGATTCCAGAGAAAATACGTGTTATTGGGATTTTTCCACCACGCCAATATATAGGCAACCATACGAATATTACTACTTTACATTACTTGGCGATAACGTATTGGGAAATTCAACTACACCTATACGTTTTCATCATTACGCCAATGTTATCCCCGCGAGCCCTATTAATATTACAGTGGTGGATAAAACACAATCTAGTGCCATGATAAGGTGGTCTGTAGGCACAATGACCGCCTTTCCACGAGAACTAATTCATAAGATCGAATATAAATCTCAATGGGATTCTAATCCTGAACATTGGCATTCTGTAAATGTGAGTGACGTTTGTAATTCGTCATCAACTTCCAATCAAACTAATTCTTATTCGAATTGTCGAGAACGTGATACCGACTATTATTATTTTAATGTAACTGATTTAAAATACCCTTTCACGCATTACGATTTTCGCATATATGTACGTTCTTCAGTTGCTCGTGGGGAGGATAAATGGTCTCCTCCTGGTTGTATAACATTGAAAACCAAGCCTTCAATACCTAGAAGACCTCCACGAACTGATGTTGGAAGCTTCGAGTGTGTTACGTCACCAGTCGACAAATCCAAAAGAGACGTGTTTATTTATTGGCAAAATATTGAAGACAACGAAAAATGTGGTGACTCATTTGAGTATCTTGCTTACTATACTTCCACAACTACAGATAACAAAACCATTATTCACCGTAGTAATGAAACATATAAGAATTATGCCAAGTTTGAAGGACTCAGTACAGACATTGGGTACAATTTTACGGTGTATTCATCAAATAAAGAAGGTTTATCAACCGATTATTCGACAATTTTCGTTCCCAATGAATCAGACAAACTTGAAGAACCGCTATCATTTACGAAAATGGCATTTGATGAACGAGGTGTATTTGAACTTTCGTGGAAAAATGCCAGTAGTCAAAAATTGTTAGCAGCTGATCAAGTCAATGATTATACTATATTTTGGTGTGAAAATGATAAGGATCGTCCATACCAGTGCAATGGTTACATGAACTGGATGCATATACCAAGTTCAGAATCTTGCTACAATATTACTGTATCGGACCATATGAAAATTTATCAATTTGCAATAAGCGCTAACAGTCAAAGCGCACTAAAGACCGGTGTTATTAGTCTTTATCAACCAACCTCTATTAGTAGTGGGATGGTATGGGCCTCATGCACAGTACTACATAATAAAATCGTTGGAAAAATAAAAAATGTCTGGGTAAATATGATTAGCTCGACGTCTATGGAATTGAGATGGAAACTTGACTGCTCTGATAGAATAGGCGCAGTTTTAGGATTTCGTATATTTTACTGTCCTGTAGTATCCATAAATAATTCCGCTTGTAAAGAACCTATGTTAAATAAGACTGTTAGTGGTGAGATGGCACAAGACAGCAGAGGAATTGCAAGCATTACAGATCTCAAGTCATATA
>domeless 2 | ACYPI004970 | JAK/STAT Pathway | | | Acyrthosiphon pisum | Brucker et al., 2012 translated using ExPASy
MTIINATAAQLRISNPPAGRDTYYCVLLLDDQLGLNHSYDNMSTAQLLSTSSSDSSTFPTPPPTSLETSGPPSLVSQTSEVGVCLNSVAVGYKPAPITNFSCISDNWVSLTCNWTKPENPIKTSYKLFFRLPGRAGGRTIINCPKDSDSRENTCYWDFSTTPIYRQPYEYYYFTLLGDNVLGNSTTPIRFHHYANVIPASPINITVVDKTQSSAMIRWSVGTMTAFPRELIHKIEYKSQWDSNPEHWHSVNVSDVCNSSSTSNQTNSYSNCRERDTDYYYFNVTDLKYPFTHYDFRIYVRSSVARGEDKWSPPGCITLKTKPSIPRRPPRTDVGSFECVTSPVDKSKRDVFIYWQNIEDNEKCGDSFEYLAYYTSTTTDNKTIIHRSNETYKNYAKFEGLSTDIGYNFTVYSSNKEGLSTDYSTIFVPNESDKLEEPLSFTKMAFDERGVFELSWKNASSQKLLAADQVNDYTIFWCENDKDRPYQCNGYMNWMHIPSSESCYNITVSDHMKIYQFAISANSQSALKTGVISLYQPTSISSGMVWASCTVLHNKIVGKIKNVWVNMISSTSMELRWKLDCSDRIGAVLGFRIFYCPVVSINNSACKEPMLNKTVSGEMAQDSRGIASITDLKSY