Source: http://cegg.unige.ch/insecta/immunodb

PGRPs: Peptidoglycan Recognition Proteins
Summary

Stephan Meister 

Kafatos/Christophides Group, Faculty of Natural Sciences, Division of Cell and Molecular Biology, Imperial College London, UK 

13 genes with 16 PGRP domains have been identified in Dm, Ag has seven genes with ten domains, and eight genes with nine domains were identified in Aa. Clear 3-way orthologous relationships could be determined for Aa genes with PGPPS1, PGRPLB, PGRPLC, PGRPLA, and PGRPLD. Surprisingly, there is an ortholog to PGRP-LE in Aa, but not in Ag. Due to lack of conservation outside the PGRP domain, most gene predictions of the PGRP family are restricted to the PGRP domain. AaPGRPLA appears to be a single domain PGRP domain gene like PGRP-LA in Dm ? and unlike PGRPLA in Ag that possesses two PGRP domains. Determination of the gene architecture of AaPGRPLC is hampered by an unsequenced region of unknown size within the gene. As a result, AaPGRPLC was initially only predicted to have one instead of three PGRP domains, however this unsequenced region is likely to contain further domains. At least one was retrieved from the unassembled sequence reads of the genome project. Likewise, a PGRP domain of a potential ninth Aa (short) PGRP gene could be found in the unassembled sequences. However, it could not be determined if it represents a pseudogene or haplotype due to lack of coverage and size of this region. The tree is built from the alignment of the PGRP domains so that genes with multiple PGRP domains have more than one branch.